Vér-agy gát patológia és farmakológia

  1. Nakagawa S, Deli MA, Kawaguchi H, Shimizudani T, Shimono T, Kittel A, Tanaka K, Niwa M.
    A new blood-brain barrier model using brain endothelial cells, pericytes and astrocytes.
    Neurochemistry International, in press, doi:10.1016/j.neuint.2008.12.002
  2. Horvát S, Fehér A, Wolburg H, Veszelka S, Tóth A, Kis L, Kurunczi A, Balogh G, Sipos P, Kürti L, Erős I, Szabó-Révész P, Deli MA.
    Sodium hyaluronate as a mucoadhesive component in nasal formulation enhances delivery of molecules to brain tissue.
    Eur. J. Pharm. Biopharm, in press, doi: 10.1016/j.ejpb.2008.10.009
  3. Deli MA.
    Potential use of tight junction modulators to reversibly open membranous barriers and improve drug delivery.
    BBA Biomembranes, doi: 10.1016/j.bbamem.2008.09.016
  4. Deli MA, Kálmán M.
    Vér-agy gát: kölcsönhatás gliasejtek és az agyi endothelsejtek között.
    In: Glia, Huszti Zs, Kálmán M (Eds.) Akadémiai Kiadó, pp. 345-368, 2008
  5. Wolburg H, Wolburg-Buchholz K, Sam H, Horvát S, Deli MA, Mack AF.
    Epithelial and endothelial barriers in the olfactory region of the nasal cavity of the rat.
    Histochem. Cell Biol. 130: 127-140, 2008
  6. Hutamekalin P, Farkas AE, Orbók A, Wilhelm I, Nagyőszi P, Veszelka S, Deli MA, Buzás K, Hunyadi-Gulyás E, Medzihradszky K, Meksuriyen D, Krizbai IA.
    Effect of cigarette smoke components on cerebral endothelial cells.
    Cell Biology International , 32: 198-209, 2008
  7. Csete M, Sipos A, Kőházi-Kis A, Szalai A, Szekeres G, Matesz A, Csákó T, Osvay K, Bor Z, Penke B, Deli MA, Veszelka S, Marti O.
    Comparative study of sub-micrometer polymeric dot-arrays, linear and crossed gratings generated by UV laser based two-beam interference as surfaces for AFM and SPR based bio-sensing.
    Appl. Surf. Science 254: 1194-1205, 2007
  8. Nakagawa S, Deli MA, Nakao S, Honda M, Hayashi K, Nakaoke R, Niwa M.
    Pericytes from brain microvessels strengthen the barrier integrity in primary cultures of rat brain endothelial cells.
    Cell. Mol. Neurobiol, 27: 687-694, 2007
  9. Csete M, Kőhazi-Kis A, Vass C, Sipos A, Szekeres G, Deli M, Osvay K, Bor Z.
    Atomic force microscopical and surface plasmon resonance spectroscopical investigation of submicrometer metal gratings generated by UV laser-based two-beam interference in Au-Ag bimetallic layers.
    Appl. Surf. Science 253: 7662-7671, 2007
  10. Deli MA.
    Blood-brain barrier models.
    In: Handbook of Neurochemistry and Molecular Neurobiology, Neural Membranes and Transport, Vol. 11, Lajtha A (Ed.), Springer, pp. 29-56, 2007
  11. Palkovits M, Deli MA, Gallatz K, Tóth ZE, Buzás E, Falus A.
    Highly activated c-fos expression in specific brain regions (ependyma, circumvenrticular organs, choroid plexus) of histidine decarboxylase deficient mice in response to formalin-induced acute pain.
    Neuropharmacology, 53: 101-112, 2007
  12. Perriere N, Cazaubon S, Chaverot N, Bourasset F, Cisternino S, Decleves X, Hori S, Terasaki T, Deli MA, Scherrmann JM, Temsamani J, Couraud PO, Roux F.
    An optimized in vitro rat blood-rain barrier model: functional expression of tight junction proteins, specific transporters and efflux pumps.
    Brain Res., 1150C: 1-13, 2007
  13. Andras I, Deli MA, Veszelka S, Hayashi K, Hennig B, Toborek M.
    The NMDA and AMPA/KA receptors are involved in glutamate-induced alterations of occludin expression and phosphorylation in brain endothelial cells.
    J. Cereb. Blood Flow Metab., 27: 1431-1443, 2007
  14. Fehér A, Erős I, Deli MA, Szabó-Révész P.
    A vér-agy gát szerepe, felépítése és gyógyszerészeti vonatkozásai.
    Gyógyszerészet, 51: 85-91, 2007
  15. Veszelka S, Pásztói M, Farkas AE, Krizbai I, Dung NTK, Niwa, M, Ábrahám CS, Deli MA.
    Pentosan polysulfate protects brain endothelial cells against bacterial lipopolysaccharide-induced damages.
    Neurochem. Int., 50: 219-228, 2007
  16. Kobayashi H, Yanagita T, Yokoo H, Sugano T, Satoh S, Kis B, Deli MA, Niwa M, Wada A.
    Induction of aquaporin 1 by dexamethason in lipid rafts in immortalized brain microvascular endothelial cells.
    Brain Res., 1123: 12-19, 2006
  17. Deli MA.
    The role of blood-brain barrier in neurodegenerative diseases.
    In: Molecular bases of Neurodegeneration, Research Signpost, Diliegro I (Ed.), pp. 137-161, 2005
  18. Csete M, Kresz N, Vass C, Kurdi G, Hainer Z, Deli MA, Bor Z, Marti O.
    Sub-micrometer adhesion modulation on polymer surfaces containing gratings produced by two-beam interference.
    Materials Science Engineering C, 25: 813-819, 2005
  19. András IE, Pu H, Tian J, Deli MA, Nath A, Hennig B, Toborek M.
    Signaling mechanisms of HIV-1 TAT-induced alterations of claudin-5 expression in brain endothelial cells.
    J. Cereb. Blood Flow Metab., 25: 1159-70, 2005
  20. Perriere N, Demeuse P, Garcia E, Regina A, Debray M, Andreux JP, Couvreur P, Schermann JM, Temsamani J, Couraud PO,Deli MA, Roux F.
    Puromycin-based purification of rat brain capillary endothelial cell cultures. Effect on the expression of blood-brain barrier specific properties.
    J. Neurochem.,93: 279-289, 2005
  21. Deli MA, Ábrahám CS, Kataoka Y, Niwa M.
    Permeability studies on in vitro blood-brain barrier models: physiology, pathology and pharmacology.
    Cell. Mol. Neurobiol, 25: 59-127, 2005
  22. Deli MA, Ábrahám CS.
    Histamine and the blood-brain barrier.
    In: Histamine Biology, Karger and SpringMed, Falus A (Ed.), pp. 264-271, 2004
  23. Kis B, Snipes JA, Deli MA, Ábrahám CS, Yamashita H, Ueta Y, Busija DW.
    Chronic adrenomedullin treatment improves blood-brain barrier function but has no effects on expression of tight junction proteins.
    Acta Neurochir., 86S: 565-568, 2003
  24. Veszelka Sz, Urbányi Z, Pázmány T, Németh L, Obál I, Dung NTK, Ábrahám CS, Szabó G, Deli MA.
    Human serum amyloid P component attenuates the bacterial lipopolysaccharide-induced increase in blood-brain barrier permeability in mice.
    Neurosci. Lett. 352: 57-60, 2003
  25. András IE, Pu H, Deli MA, Nath A, Hennig B, Toborek M.
    HIV-1 Tat protein selectively disrupts tight junctions in cultured brain endothelial cells.
    J. Neurosci. Res. 74: 255-265, 2003
  26. Gellén B, Kovács J, Németh L, Németh P, Vágvölgyi J, Bari F, Megyeri P. Pintér S, Temesvári P, Deli MA, Vecsernyés M, Szilvássy Z, Koltai M, Ábrahám CS.
    Vascular changes playing a role in the pathogenesis of necrotizing enterocolitis in asphyxiated newborn pigs.
    Pediatr. Surg. Int., 19: 380-384, 2003
  27. Krizbai IA, Deli MA.
    Signalling pathways regulating tight junction permeability in the blood-brain barrier.
    Cell. Mol. Biol., 49: 23-32, 2003
  28. Kis B, Ábrahám CS, Deli MA, Kobayashi H, Yamashita H, Busija DW, Ueta Y.
    Adrenomedullin, an autocrine mediator of the blood-brain barrier function.
    Hypertens. Res., 26: S61-S70, 2003
  29. Deli MA, Ábrahám CS, Niwa M, Falus A.
    N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine increases the permeability of primary mouse cerebral endothelial cell monolayers.
    Infl. Res., 52: S39-S40, 2003
  30. Kis B, Ábrahám CS, Deli MA, Ueta Y.
    Adrenomedullin and migraine.
    Headache, 42: 1064-1065, 2002
  31. Ábrahám CS, Harada N, Deli MA, Niwa M.
    Transient forebrain ischemia increases the blood-brain barrier permeability for albumin in stroke-prone spontaneously hypertensive rats.
    Cell. Mol. Neurobiol, 22: 455-462, 2002
  32. Kis B, Kaiya H, Nishi R, Deli MA, Ábrahám CS, Yanagita T, Isse T, Gotoh S, Kobayashi H, Wada A, Niwa M, Kangawa K, Greenwood J, Yamashita H, Ueta Y.
    Cerebral endothelial cells are a major source of adrenomedullin.
    J. Neuroendocrinol., 14: 283-293, 2002
  33. Kis B, Deli MA, Kobayashi H, Ábrahám CS, Yanagita T, Kaiya H, Isse T, Nishi R, Gotoh S, Kangawa K, Wada A, Greenwood J, Niwa M, Yamashita H, Ueta Y.
    Adrenomedullin regulates blood-brain barrier functions in vitro.
    NeuroReport, 12:, 4139-42, 2001
  34. Huszti Z, Horváth-Sziklai A, Noszál B, Madarász E, Deli MA.
    Enhancing effect of zinc on astroglial and cerebral endothelial histamine uptake.
    Biochem. Pharmacol., 62: 1491-1500, 2001
  35. Kis B, Ábrahám CS, Deli MA, Kobayashi H, Wada A, Niwa M, Yamashita H, Ueta Y.
    Adrenomedullin in the cerebral circulation.
    Peptides, 22: 1825-34, 2001
  36. Kovács J, Julesz J, Mogyoróssy MV, Deli MA, Ábrahám CS, Vecsernyés M.
    Asphyxia-induced release of alpha-melanocyte-stimulating hormone in newborn pigs.
    Peptides, 22:1049-1053, 2001
  37. Deli MA, Ábrahám CS, Takahata H, Niwa M.
    Tissue plasminogen activator inhibits P-glycoprotein activity in brain endothelial cells.
    Eur. J. Pharmacol., 411: R3-R5, 2001
  38. Deli MA, Sakaguchi S, Nakaoke R, Ábrahám CS, Takahata H, Kopacek J, Shigematsu K, Katamine S, Niwa M.
    PrP fragment 106-126 is toxic to cerebral endothelial cells expressing PrPC
    NeuroReport, 11: 3931-3936, 2000
  39. Deli MA, Ábrahám CS, Takahata H, Katamine S, Niwa M.
    Pentosan polysulfate regulates scavenger receptor-mediated, but not fluid-phase, endocytosis in immortalized cerebral endothelial cells.
    Cell. Mol. Neurobiol., 20: 731-745, 2000
  40. Deli MA, Németh L, Falus A, Ábrahám CS.
    Effect of N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine on the blood-brain barrier permeability in the rat.
    Eur. J. Pharmacol., 387: 63-72, 2000
  41. Ábrahám CS, Deli MA, Temesvári P, Kovács J, Szerdahelyi P, Joó F, Torpier G.
    Asphyxia- and reperfusion-induced regional differences in cytotoxic and vasogenic brain edema formation in newborn pigs. Neurosci.
    Res. Commun., 25: 173-182, 1999
  42. Megyeri P, Deli MA, Ábrahám CS.
    Mannose-binding lectin and meningococcal disease.
    Lancet, 354: 338, 1999
  43. Németh L, Szabó CA, Deli MA, Kovács J, Krizbai IA, Ábrahám CS.
    Cerebral microvascular acid phosphatase isoenzymes may contribute to the histamine-induced changes in the blood-brain barrier permeability in newborn pigs.
    Neurosci. Res. Commun., 24: 125-133, 1999
  44. Megyeri P, Németh L, Pabst KM, Pabst MJ, Deli MA, Ábrahám CS.
    4-(2-aminoethyl)benzenesulfonyl fluoride, a serine protease inhibitor, protects against tumor necrosis factor ?-induced vasogenic brain edema formation in newborn pigs.
    Eur. J. Pharmacol., 374: 207-211, 1999
  45. Deli MA, Niwa M, Katamine S, Ábrahám CS.
    Pentosan in transmissible spongiform encephalopathies.
    Lancet, 353: 1272, 1999
  46. Kis B, Szabó CA, Pataricza J, Krizbai I, Mezei Zs, Gecse Á, Telegdy Gy, Papp JGy, Deli MA.
    Vasoactive substances produced by cultured rat brain endothelial cells: a comparison of primary cells and immortalized cell lines.
    Eur. J. Pharmacol., 368: 35-42, 1999
  47. Krizbai IA, Deli MA, Pestenácz A, Siklós L, Szabó CA, András I, Joó F.
    Expression of glutamate receptors on cultured cerebral endothelial cells.
    J. Neurosci. Res., 54: 814-819, 1998
  48. Németh L, Deli MA, Falus A, Szabó CA, Ábrahám CS.
    Cerebral ischemia-reperfusion induced vasogenic brain edema formation in rats: effect of an intracellular histamine receptor antagonist.
    Eur. J. Pediatr. Surg., 8: 216-219, 1998
  49. Fábián G, Szabó CA, Bozó B, Greenwood J, Adamson P, Deli MA, Joó F, Krizbai I, Szücs M.
    Expression of G-protein subtypes in cultured cerebral endothelial cells.
    Neurochem. Int., 33: 179-185, 1998
  50. Farkas Gy, Márton J, Nagy Zs, Mándi Y, Takács T, Deli MA, Ábrahám CS.
    Experimental acute pancreatitis results in increased blood-brain barrier permeability in rats: a potential role for tumor necrosis factor and interleukin 6.
    Neurosci. Lett., 242: 147-150, 1998
  51. Szabó CA, Deli MA, Németh L, Krizbai I, Kovács J, Ábrahám CS, Joó F.
    Histamine-induced vasogenic brain oedema formation in newborn pigs: a role for endothelial acid phosphatase?
    In: Neurochemistry: Cellular, Molecular and Clinical Aspects, Plenum Publishing Corporation, Telkeen AW, Korf J (Eds.), pp. 479-483, 1997.
  52. Deli MA, Ábrahám CS, Dung NTK, Joó F.
    Preparation of primary cultures of cerebral endothelial cells from newborn pigs.
    Drug transport across the blood-brain barrier: in vivo and in vitro techniques, de Boer ABG, Sutanto W (Eds.), Harwood Academic Publishers, pp. 85-89, 1997
  53. Deli MA, Szabó CA, Dung NTK, Joó F.
    Immunohistochemical and electron microscopy detections on primary cultures of rat cerebral endothelial cells.
    Drug transport across the blood-brain barrier: in vivo and in vitro techniques, de Boer ABG, Sutanto W (Eds.), Harwood Academic Publishers, pp. 23-28, 1997
  54. Szabó CA, Deli MA, Dung NTK, Joó F.
    Production of pure primary rat cerebral endothelial cell culture: a comparison of different methods.
    Neurobiology, 5: 1-16, 1997
  55. Németh L, Szabó CA, Deli MA, Kovács J, Krizbai IA, Ábrahám CS, Joó F.
    Intra-carotid histamine administration results in a dose-dependent vasogenic brain oedema formation in new-born pigs.
    Inflamm. Res., 46: S45-S46, 1997
  56. Huszti Z, Madarász E, Schlett K, Joó F, Szabó CA, Deli MA.
    Mercury-stimulated histamine uptake and binding in cultured astroglial and cerebral endothelial cells.
    J. Neurosci. Res., 48: 71-81, 1997
  57. Deli MA, Joó F.
    Cultured vascular endothelial cells of the brain.
    Keio J. Med., 45:, 183-199, 1996
  58. Szabó CA, Krizbai I, Deli MA, Ábrahám CS, Joó F.
    Receptor-mediated regulation by histamine of the acid phosphatase activity in cultured cerebral endothelial cells.
    Biology and physiology of the blood-brain barrier: transport, cellular interactions and brain pathologies, Couraud PO and Scherman (eds), Plenum Publishing Corporation, pp. 241-243, 1996
  59. Imaizumi S, Kondo T, Deli MA, Gobbel G, Joó F, Epstein CJ, Yoshimoto T, Chan PH.
    The influence of oxygen free radicals on the permeability of the monolayer of cultured brain endothelial cells.
    Neurochem. Int., 29: 205 211, 1996
  60. Ábrahám CS, Deli MA, Joó F, Megyeri P, Torpier G.
    Intracarotid tumor necrosis factor-alpha administration increases the blood-brain barrier permeability in cerebral cortex of the newborn pig: quantitative aspects of double-labelling studies and confocal laser scanning analysis.
    Neurosci. Lett., 208: 85-88, 1996
  61. Szabó CA, Krizbai I, Deli MA, Ábrahám CS, Joó F.
    Receptor-mediated regulation by histamine of the acid phosphatase activity in cultured cerebral endothelial cells.
    Inflamm. Res., 45: S60-S61, 1996
  62. Deli MA, Descamps L, Dehouck M-P, Cecchelli R, Joó F, Ábrahám CS, Torpier G.
    Exposure of tumor necrosis factor alpha to the luminal membrane of bovine brain capillary endothelial cells cocultured with astrocytes induces a delayed increase of permeability and cytoplasmic stress fiber formation of actin.
    Neurosci. Res., 41: 717-726, 1995
  63. Krizbai I, Szabó G, Deli MA, Maderspach K, Lehel Cs, Oláh Z, Wolff JR, Joó F.
    Expression of protein kinase C family members in the cerebral endothelial cells.
    J. Neurochem., 65: 459-462, 1995
  64. Deli MA, Dehouck M-P, Ábrahám CS, Cecchelli R, Joó F.
    Penetration of small molecular weight substances through cultured bovine brain capillary endothelial cell monolayers: the early effects of 3',5'-cyclic adenosine monophosphate.
    Exp. Physiol., 80: 675-678, 1995
  65. Huszti Z, Deli MA, Joó F.
    Carrier-mediated uptake and release of histamine by cultured rat cerebral endothelial cells.
    Neurosci. Lett., 184: 185-188, 1995
  66. Deli MA, Dehouck M-P, Cecchelli R, Ábrahám CS, Joó F.
    Histamine induces a selective albumin permeation through the blood-brain barrier in vitro.
    Inflamm. Res., 44 S1: S56-S57, 1995
  67. Deli MA, Dung NTK, Joó F.
    Isolation and culture of endothelial cells from cortical microvessels of the rat and the piglet.
    Drug transport across the blood-brain barrier (BBB): new experimental strategy. An overview of Endothelial Cell Culture and Microdialysis Techniques as Tools to Study BBB transport, de Boer ABG and Sutanto W (eds), BIOMED-Concerted Action, Leiden, pp. 175-188, 1994
  68. Kondo T, Imaizumi S, Kato I, Deli MA, Joó F, Chan PH, Epstein CJ, Yoshimoto T.
    Effect of free radicals on the permeability of the blood-brain barrier - using in vitro blood-brain barrier model of human SOD transgenic mouse (in Japanese).
    No To Shinkei, 46: 1155 61, 1994
  69. Krizbai I, Deli MA, Lengyel I, Maderspach K, Pákáski M, Joó F, Wolff JR.
    In situ hybridization with digoxigenin labeled oligonucleotide probes: detection of CAMK-II gene expression in primary cultures of cerebral endothelial cells.
    Neurobiology, 1: 235-240, 1993
  70. Deli MA, Joó F, Krizbai I, Lengyel I, Nunzi GM, Wolff JR.
    Calcium/calmodulin stimulated protein kinase II is present in primary cultures of cerebral endothelial cells.
    J. Neurochem., 60: 1960-1963, 1993