|
BBB functions in physiological and pathological
conditions - modelling BBB changes in prion diseases, Alzheimer disease and other pathologis - role of histamine in the regulation of BBB functions - protection of the BBB in pathological conditions by therapeutical molecules eg. pentosan |
 Fluorescent microscopical image of immunstaining for tight junction protein ZO-1 in brain endothelial cells under control conditions and after treatment with beta-amyloid peptide. |
| Drug
targeting to
brain - circumventing the BBB by nasal application of drugs: role of mucoadhesive properties in formulations - construction of niosomes (nanoparticles made from nonionic surfactants) that target transport systems at the BBB to deliver therapeutical molecules to brain |
 An atomic force microscopy image of niosomes on polymer surface structured by laser gratings (collaboration: Departments of Pharmacautical Technology and Optics; Quantum Electronics, University of Szeged) |
| Nasal pathway
- modelling the nasal epithelium for drug transport studies, comparison with other barriers -testing different formulations for effective nasal transport of active ingredients to the systemic circulation |
 Structure of the olfactory system (collaboration: University of Tubingen, Germany). Claudin-5 and ZO-1 immunostaining. |
